2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W700665
    5-Hydroxy indomethacin
    5-Hydroxy indomethacin (O-Desmethyl indomethacin) is a metabolite of Indomethacin (HY-14397).
    5-Hydroxy indomethacin
  • HY-121899R
    1-Oxo Ibuprofen (Standard)
    1-Oxo Ibuprofen (Standard) is the analytical standard of 1-Oxo Ibuprofen. This product is intended for research and analytical applications. 1-Oxo Ibuprofen (Ibuprofen EP impurity J) is a degradation product and a potential impurity in preparations of Ibuprofen. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.
    1-Oxo Ibuprofen (Standard)
  • HY-W008216R
    HMMNI (Standard)
    HMMNI (Standard) (Hydroxy Dimetridazole (Standard)) is the analytical standard of HMMNI (HY-W008216). This product is intended for research and analytical applications. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class drug that combats protozoan infections.
    HMMNI (Standard)
  • HY-180463
    Rubradirin aglycone
    Rubradirin aglycone (Compound 7) is an aglycone of Rubradirin and can be obtained by mild acid hydrolysis of Rubradirin.
    Rubradirin aglycone
  • HY-W654227
    7-Hydroxy methotrexate-d3 ammonium salt
    7-Hydroxy methotrexate-d3 (ammonium salt) is deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    7-Hydroxy methotrexate-d<sub>3</sub> ammonium salt
  • HY-139433
    6-Hydroxy etodolac
    6-Hydroxy etodolac (compound 2) is a metabolite of Etodolac (HY-76251). Etodolac is a non-steroidal anti-inflammatory compound and is a COX inhibitor.
    6-Hydroxy etodolac
  • HY-122813
    Dabigatran acyl-β-D-glucuronide
    Dabigatran acyl-β-D-glucuronide is an active metabolite of the thrombin inhibitor Dabigatran (HY-10163). Dabigatran acyl-β-D-glucuronide increases activated partial thromboplastin time (aPTT) in isolated human platelet-poor plasma.
    Dabigatran acyl-β-D-glucuronide
  • HY-135577
    β-Apooxytetracycline
    		99.0%
    β-Apooxytetracycline is a degradation product of Oxytetracycline (HY-B0275). Oxytetracycline is a widespread antibiotic.
    β-Apooxytetracycline
  • HY-W653727
    BTS44596
    BTS44596 (Prochloraz-desimidazole-formylamino) is a metabolite of the antifungal agent Prochloraz (HY-B0845). BTS44596 is one of the core target analytes for regulatory monitoring of Prochloraz residue limits in fruits and vegetables as well as for simultaneous detection via LC-MS/MS.
    BTS44596
  • HY-W587774
    6-Hydroxy monopropylheptylphthalate
    6-Hydroxy monopropylheptylphthalate is a metabolite of di (isononyl) cyclohexane-1,2-dicarboxylate (DINCH) , an alternative for phthalate plasticizers.
    6-Hydroxy monopropylheptylphthalate
  • HY-100085R
    21-Desacetyldeflazacort (Standard)
    21-Desacetyldeflazacort (Standard) is the analytical standard of 21-Desacetyldeflazacort. This product is intended for research and analytical applications. 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.
    21-Desacetyldeflazacort (Standard)
  • HY-W009265
    4-Octylphenol diethoxylate
    4-Octylphenol diethoxylate (Octoxynol-2) is an endogenous estradiol like endocrine disrupter. 4-Octylphenol diethoxylate is the water contaminant.
    4-Octylphenol diethoxylate
  • HY-W714180
    Desmethyl-formamido-pirimicarb
    Desmethyl-formamido-pirimicarb is an intermediate metabolite of Pirimicarb (HY-119419). Desmethyl-formamido-pirimicarb is detected in both Pirimicarb-exposed soil environments and advanced oxidation water treatment processes.
    Desmethyl-formamido-pirimicarb
  • HY-12765R
    Losartan Carboxylic Acid (Standard)
    Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[4].
    Losartan Carboxylic Acid (Standard)
  • HY-G0011
    Netupitant metabolite Netupitant N-oxide
    Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
    Netupitant metabolite Netupitant N-oxide
  • HY-W349628
    Dibutyl 3-hydroxybutyl phosphate
    Dibutyl 3-hydroxybutyl phosphate is a predominant metabolite of tris( n-butyl) phosphate (TNBP). TNBP is a commonly used alkyl organophosphate ester.
    Dibutyl 3-hydroxybutyl phosphate
  • HY-W585931
    Fipronil sulfide
    Fipronil sulfide is a toxic, persistent metabolite of Fipronil (HY-B0822). Fipronil is a broad-spectrum insecticide.
    Fipronil sulfide
  • HY-183151
    1β-Hydroxytaurodeoxycholic acid
    1β-Hydroxytaurodeoxycholic acid is a metabolite of Deoxycholic Acid (HY-N0593).
    1β-Hydroxytaurodeoxycholic acid
  • HY-Z8447
    9(E)-Erythromycin A oxime
    		Control
    (9E)-Erythromycin A oxime is a metabolite of Roxithromycin (HY-B0435). Roxithromycin is a semi-synthetic macrolide antibiotic.
    9(E)-Erythromycin A oxime
  • HY-174439
    Nsp12-IN-2
    Nsp12-IN-2 (Compound 8), the triphosphate metabolite of 4'-thiouridine (HY-W113081), is a SARS-CoV-2 Nsp12 inhibitor. Nsp12-IN-2 inhibits the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, terminates RNA synthesis and also blocks the RNAylation and NMPylation of Nsp9. Nsp12-IN-2 is promising for research of infections caused by SARS-CoV-2, other coronaviruses, and other RNA viruses.
    Nsp12-IN-2
Cat. No. Product Name / Synonyms Application Reactivity